Current Issue : January - March Volume : 2021 Issue Number : 1 Articles : 6 Articles
Objective. Breast cancer (BC) affects women all over the world. This study aimed at screening out potential biomarkers through\nperforming an in-depth analysis of data from the previous research and database. Design. This study made full use of RNA\nsequencing (RNA-seq) data from cancer genomic maps (TCGA) and screened key genes related to stemness by merging WGCNA\nwith BC mRNAsi......................................
Background. The prognosis of patients with extensive-stage small cell lung cancer (SCLC) is poor. Adding an immune checkpoint\ninhibitor (ICI) to chemotherapy may exert a synergistic effect and improve survival outcomes. However, for treatment-naive\nextensive-stage SCLC patients, the efficacy of immunotherapy in combination with cytotoxic chemotherapy remains controversial.\nObjective. To evaluate the benefits and risks of the combination of immunotherapy and chemotherapy and to assess the\ncomparative effectiveness of different first-line treatment strategies for extensive-stage SCLC. Methods. PubMed, Web of Science,\nEMBASE, and Cochrane Library were searched for randomized clinical trials studying different immunotherapeutics for patients\nwith previously untreated extensive-stage SCLC up to Feb 16, 2020. The primary outcomes were overall survival (OS) and\nprogression-free survival (PFS), and the secondary outcomes were objective response rate (ORR), disease control rate (DCR), and\nadverse events........................
Objective: To retrospectively analyze the prognostic differences between\nLCC and RCC, and to explore the occurrence of such differences in the relevant\nfactors. Provide clinical basis for the individualization and precise\ntreatment of CRC. Methods: The clinical and follow-up data of 155 T4 CRC\npatients who underwent surgery in the first Affiliated Hospital of Sun\nYat-sen University between August, 1994 and December, 2005. The age,\nsex, family history, staging, pathologic features, DFS, OS and other information\nwere collected. The survival of the LCC (Left colon cancer) and\nRCC (Right colon cancer) patients was analyzed by Kaplan-Meier method.\nThe survival curves of the LCC and RCC patients were compared by\nlog-rank test. Results: There are statistically significant differences in N\nstage, CCR, family history and histological grade between two groups.\nGender, histological grade and CCR were factors associated with OS and\nDFS of the T4 LCC according to the univariate and multivariate analyses. In\naddition, only the CCR was found to be the factor associated with OS and\nDFS of the T4 RCC..................................
Purpose. We aimed to retrospectively investigate the prognostic worth of pretreatment advanced lung cancer inflammation index\n(ALI) in locally advanced nasopharyngeal carcinoma (LA-NPC) patients treated with concurrent chemoradiotherapy (C-CRT).\nPatients and Methods. A total of 164 LA-NPC patients treated with cisplatinum-based definitive C-CRT were included in this\nretrospective cohort analysis. The convenience of ideal pre-C-CRT ALI cut-offs affecting survival results was searched by employing\nthe receiver operating characteristic (ROC) curve analyses. The primary endpoint was the link between the ALI groups and overall\nsurvival (OS), while cancer-specific survival (CSS), locoregional progression-free survival [LR(PFS)], distant metastasis-free survival\n(DMFS), and PFS comprised the secondary endpoints. Results.The ROC curve analyses distinguished a rounded ALI cut-off score of\n24.2 that arranged the patients into two cohorts............................
Purpose. Due to the rarity, it is difficult to predict the survival of patients with fibrosarcoma. This study aimed to apply a\nnomogram to predict survival outcomes in patients with fibrosarcoma. Methods. A total of 2235 patients with diagnoses of\nfibrosarcoma were registered in the Surveillance, Epidemiology, and End Results database, of whom 663 patients were eventually\nenrolled. Univariate and multivariate Cox analyses were used to identify independent prognostic factors. Nomograms were\nconstructed to predict 3-year and 5-year overall survival and cancer-specific survival of patients with fibrosarcoma. Results. In\nunivariate and multivariate analyses of OS, age, sex, race, tumor stage, pathologic grade, use of surgery, and tumor size were\nidentified as independent prognostic factors. Age, sex, tumor stage, pathologic grade, use of surgery, and tumor size were\nsignificantly associated with CSS. These characteristics were further included to establish the nomogram for predicting 3-year and\n5-year OS and CSS. For the internal validation of the nomogram predictions of OS and CSS, the C-indices were 0.784 and 0.801.\nConclusion. We developed the nomograms that estimated 3-year and 5-year OS and CSS. These nomograms not only have good\ndiscrimination performance and calibration but also provide patients with better clinical benefits....
Background. This retrospective study aimed to characterize the long-term (>24 months) safety profile of zoledronic acid (ZA). We\naimed to investigate whether long-term ZA treatment had greater benefits than short-term treatment in patients from southern\nChina with advanced breast cancer (ABC) with bone metastasis. Patients and Methods. A total of 566 metastatic breast cancer\ncases were included and divided into two groups according to the duration of ZA treatment. The included patients had at least one\nlytic bone lesion and had no skeletal-related events (SREs) prior to ZA therapy.Theprimary endpoint was to analyze the safety and\nlong-term adverse effects, which covered osteonecrosis of jaws (ONJ), renal impairment, and hearing impairment. The second\nobjective was to determine the efficacy of long-term ZA treatment by the incidence of SREs. Results. Fifteen patients were\ndiagnosed with........................
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